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Dr Syme, 78, said after watching state Parliaments reject 16 euthanasia bills over the past 20 years he was ready to out himself and be charged over Mr Guest's death because a court case could set a useful legal precedent for doctors who are too scared to help terminally ill people end their own lives. In the same graph, the solid black line indicates the actual target position, while the dashed black line indicates the average target position as determined from the past 200 ms. This is an average from a rather broad spectrum of values (20-500 ms) which have been suggested in the literature as an integration window for perceiving the position of (suddenly appearing) moving objects (Krekelberg and Lappe, 2001; Kerzel and Gegenfurtner, 2004). In our data set, saccade latencies varied between 180 and 348 ms, while saccade processing times ranged from 252 to 412 ms. Considering the data based on processing time (green symbols and linear regression), the amplitudes fell short off the current target position for saccades with the shortest latencies, while saccades with the longest latencies came close to the current target position. To this end, we compared the mean activity within the same time window (−80-0 ms) for saccades toward moving targets and amplitude-matched saccades toward stationary targets by means of a Mann-Whitney rank test. The purpose for choosing this time window was two-fold. By choosing this latter value (i.e., 250 ms) we avoided interference of baseline discharges with visually induced and/or presaccadic burst activity. First, it was early enough to contain visually induced activity and late enough to contain saccade-related motor signals. To this end, we analyzed perisaccadic activity for saccades into four different directions (left, right, up, and down) within a fixed perisaccadic window, i.e., from 150 ms before until 150 ms after saccade onset. −80 to 0 ms, i.e., from 80 ms before saccade onset until saccade onset. In the MMTs, after initial central fixation, the target always stepped to 20° eccentricity (i.e., the most eccentric stationary target location) and immediately started to move centripetally at 30°/s. As described above, a variance in saccade onset latency induces automatically a variance in saccade amplitude in order to adequately catch-up with the moving target. For monkey C, the target always stepped toward the most eccentric target distance and immediately thereafter started to move centripetally. For those neurons, which were tested for saccades toward stationary and moving targets, we determined, whether their presaccadic activity was tuned for target distance or saccade amplitude by means of an ANOVA on ranks. These four values were compared with baseline activity, i.e., spontaneous activity from 650 to 250 ms before saccade onset, using an ANOVA on ranks. Electrical activity was amplified through a Grass 6-channel amplifier and was visualized on a cathode-ray tube. In a final step, we determined whether the activity for saccades toward stationary and toward moving targets was significantly different. We classified each of these 229 initial saccades according to their amplitude into one of the previously specified eight bins. Initial anesthesia was performed using Ketamine (monkey C) or Rompun/Ketamine (monkey K) respectively. For monkey C, after initial central fixation, stationary targets appeared at one of eight eccentric distances, ranging from 6° to 20° in two-degree steps. The filly's seizure episodes were preceded by several walking steps on her hind legs, resembling the dance of a circus bear. In monkey C, saccade target distances ranged from 6° to 20° eccentricity in two-degree steps (6°, 8°, 10°, 12°, 14°, 16°, 18°, 20°). In monkey K, due to the spatial limitation of the visual display, saccade target distances ranged from 7° to 12° (for vertical saccades), or 9° to 14° (for horizontal saccades), in equidistant steps. Hence, if our decoder for saccade amplitude would correctly perform (see below), this would mean that we would be able to predict the amplitude of an upcoming saccade. Figure 5. Saccade amplitude as function of latency or processing time. The orange (latency) and light-green (processing time) straight-lines indicate the respective linear regression functions for these two data sets. Saccade amplitudes are shown for moving target trials from monkey C as function of (i) saccade latency (red data points) or (ii) as function of processing time (green data points). While the above analysis determined the distribution of saccade amplitudes, it did not quantify the accuracy of the saccade landing points with respect to the moving target. The particular time for the emergence of withdrawal symptoms will depend on the factors mentioned above. This c ontent has been w ri tt en by GSA Content Generat or DEMO!
